Web Links: Malaria
| NPR | |
| Cutting Trees In The Amazon Triggers A Jump In Malaria If a tree falls in the Amazon, does it matter to malaria-carrying mosquitoes? Some mosquitoes that transmit malaria don't like the rain forest much. Yes, say researchers from the University of Wisonsin-Madison. They found that a 4 percent reduction in rain forest led to a 50 percent increase in malaria cases in the western tip of Brazil, even a decade after the trees were cut. |
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| Date Added: June 19 2010 | Visits: 14 |
| Buzzle.com | |
| Malaria: New Hope For The Number 2 Biggest Killer By Infection On The Planet Malaria is the second biggest cause of death by infection on Earth, whilst in Africa it is number 1, claiming 5 million victims per year. In adults if often reoccurs, whilst the resistance diminishes over time. Malaria primarily kills the elderly, pregnant women and children. It is caused by the protozoan parasite and spread by mosquitoes in the tropical and sub-tropical regions. To add insult to injury, it is usually the poorest people that are at most risk. |
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| Date Added: June 05 2010 | Visits: 18 |
| PLOS | |
| A Systems-Based Analysis of Plasmodium vivax Lifecycle Transcription from Human to Mosquito Up to 40% of the world's population is at risk for Plasmodium vivax malaria, a disease that imposes a major public health and economic burden on endemic countries. Because P. vivax produces latent liver forms, eradication of P. vivax malaria is more challenging than it is for P. falciparum. Genetic analysis of P. vivax is exceptionally difficult due to limitations of in vitro culture. To overcome the barriers to traditional molecular biology in P. vivax, we examined parasite transcriptional changes in samples from infected patients and mosquitoes in order to characterize gene function, define regulatory sequences and reveal new potential vaccine candidate genes. |
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| Date Added: May 23 2010 | Visits: 18 |
| Nature.com | |
| Chemical genetics of Plasmodium falciparum Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and resistance has emerged for most antimalarial drugs. To discover new antimalarial chemotypes, we have used a phenotypic forward chemical genetic approach to assay 309,474 chemicals. Here we disclose structures and biological activity of the entire library—many of which showed potent in vitro activity against drug-resistant P. falciparum strains—and detailed profiling of 172 representative candidates. A reverse chemical genetic study identified 19 new inhibitors of 4 validated drug targets and 15 novel binders among 61 malarial proteins. Phylochemogenetic profiling in several organisms revealed similarities between Toxoplasma gondii and mammalian cell lines and dissimilarities between P. falciparum and related protozoans. One exemplar compound displayed efficacy in a murine model. Our findings provide the scientific community with new starting points for malaria drug discovery. |
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| Date Added: May 23 2010 | Visits: 23 |
| Science Direct | |
| Use of magnetically purified Plasmodium falciparum parasites improves the accuracy of erythrocyte invasion assays Merozoite invasion of erythrocytes is a crucial step for the asexual cycle of Plasmodium falciparum. Multiple invasion pathways, which involve different ligand-receptor interactions, have been identified in P. falciparum by examining the entry of purified parasite into erythrocytes with different surface receptors, either mutant or under different enzyme treatments. The most critical step for a successful invasion assay is the isolation of erythrocytes infected with viable schizonts. Here, we applied a magnetic column to purify the schizonts for the erythrocyte invasion assay. Comparing to Percoll-sorbitol purification method, this modified approach showed great improvement on reproducibility and reliability of invasion assay, particularly for short-term, culture-adapted parasite isolates. The magnetic purification method is an excellent alternative for parasite isolates that do not tolerate or with unknown sensitivity to Percoll-sorbitol exposure. |
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| Date Added: May 23 2010 | Visits: 48 |
| 7th Space.com | |
| Severe neurological sequelae and behaviour problems after cerebral malaria in Ugandan children. Cerebral malaria is the most severe neurological complication of falciparum malaria and a leading cause of death and neuro-disability in sub-Saharan Africa. This study aimed to describe functional deficits and behaviour problems in children who survived cerebral malaria with severe neurological sequelae and identify patterns of brain injury.FindingsRecords of children attending a specialist child neurology clinic in Uganda with severe neurological sequelae following cerebral malaria between January 2007 and December 2008 were examined to describe deficits in gross motor function, speech, vision and hearing, behaviour problems or epilepsy. |
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| Date Added: April 17 2010 | Visits: 31 |
| eMJA - The Medical Journal of Australia | |
| Important information regarding the close monitoring of a returning treveller's declining health, especially regarding potential Malaria infections or other mosquito borne diseases | |
| Date Added: March 28 2010 | Visits: 19 |
| Malaria No More - January 21, 2010 | |
| Gorillas Cause Trouble for Malaria Eradication In a new study, researchers found that Gorillas carry malaria. This is good news for humans because now gorillas could aid us in developing a malaria vaccine. However, this is also bad news for humans because gorillas could aid in the malaria infection rate. Scientist tested gorillas in Cameroon and Gabon and found the malaria parasite Plasmodium falciparum present, which was previously believed to only infect humans. This is trouble because Plasmodium falciparum is the deadliest of the malaria strains and prevalent in sub-Saharan Africa |
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| Date Added: January 24 2010 | Visits: 111 |
| The Malaria Journal - January 11, 2010 | |
| Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post- mortem findings from a fatal case of knowlesi malaria are reported here. |
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| Date Added: January 11 2010 | Visits: 49 |
| National Institute of Alleregy and Infectious Diseases (NIAID) | |
| NIAID Malaria Research Program web site. | |
| Date Added: December 22 2009 | Visits: 38 |
| BBC Health | |
| BBC Health malaria information site. | |
| Date Added: December 22 2009 | Visits: 41 |
| The Travel Doctor | |
| Malaria information page. Lots of diagrams and useful information about Malaria. | |
| Date Added: December 22 2009 | Visits: 46 |
| Medicinenet | |
| Malaria - symptoms - signs - treatment etc. | |
| Date Added: December 22 2009 | Visits: 30 |
| Malaria Hot Spots | |
| This site is an educational initiative by GlaxoSmithKline Travel Health. You can find out about the country you are going to travel to and what the risks are likely to be. |
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| Date Added: December 22 2009 | Visits: 39 |
| CDC Website | |
| Human Plasmodium knowlesi Infection Detected by Rapid Diagnostic Tests for Malaria We describe a PCR-confirmed case of Plasmodium knowlesi infection with a high parasitemia level and clinical signs of severe malaria in a migrant worker from Malaysian Borneo in the Netherlands. Investigations showed that commercially available rapid antigen tests for detection of human Plasmodium infections can detect P. knowlesi infections in humans. |
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| Date Added: September 10 2009 | Visits: 92 |
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