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Web Links: Malaria Vaccine
Xconomy.com - May 13, 2010
Seattle BioMed Starts Malaria Trial

Seattle Biomedical Research Institute said today it has officially started the first human clinical trial of its malaria vaccine candidate. The trial will assess the safety of a genetically engineered version of the malaria parasite. I wrote about this trial in depth back in March based on an interview with Seattle BioMed’s lead researcher on the program, Stefan Kappe. If the vaccine candidate passes this initial safety test, the Seattle-based nonprofit said it plans to start a mid-stage trial, in late 2010 or early 2011, to examine the vaccine’s effectiveness.
Date Added: May 13 2010 Visits: 26
Peace FM Online - April 6, 2010
1,500 Ghanaians Participate In Malaria Vaccine Efficacy

More than one thousand 500 Ghanaians, mainly from Kintampo, are participating in the third phase of a trial to determine the efficacy of the first vaccine for malaria. About 16,000 children in two age groups - six to 10 weeks and five to 17 months are being selected from seven African countries, for the three-year trial.
Date Added: April 06 2010 Visits: 26
Pharmaceutical Business Review - April 6, 2010
Crucell, GlaxoSmithKline Biologicals To Jointly Develop Malaria Vaccine

Crucell, a Dutch biopharmaceutical company, has signed a binding letter of agreement with GlaxoSmithKline Biologicals (GSK) to collaborate on developing malaria vaccine candidate.

The pre-clinical data from earlier studies indicated enhanced immune responses against the malaria parasite (circumsporozoite stage of the Plasmodium falciparum) when Crucell's Adenovirus (AdVac) technology and GSK's RTS,S/AS technology are used in combination, versus either component alone.
Date Added: April 06 2010 Visits: 44
Newz for Me - February 6, 2010
New Malaria Vaccine Is Safe and Protective in Children, Scientists Find

A new vaccine to prevent the deadly malaria infection has shown promise to protect the most vulnerable patients -- young children -- against the disease, according to an international team of researchers led by the University of Maryland School of Medicine's Center for Vaccine Development (CVD) and the Malaria Research and Training Center at the University of Bamako in Mali, West Africa

Date Added: February 05 2010 Visits: 30
Medical News Today - February 4, 2010
Billion Dollar Market For Malaria Vaccine Products Should Interest Drug Developers

With increased attention on finding a cure for the scourge of malaria, recently highlighted by the announcement of a large research and development grant from the Bill Gates Foundation, and with several candidates already in the pipeline, there could be a $1 billion market for malaria vaccine products by 2017, according to healthcare market research publisher Kalorama Information, which recently published a survey of emerging vaccine products titled: "What's Next in Vaccines? HIV, Malaria, Rabies, MRSA, and 30 Other Vaccine Targets in the 2010-2020 Pipeline." According to Kalorama, the potential market is likely to spur companies to develop innovative products for a disease that kills nearly two million people each year.
Date Added: February 05 2010 Visits: 43
Time Magazine - January 15, 2010
Hopes for a New Kind of Malaria Vaccine

Malaria was eradicated in the U.S. by 1951, so Americans can be forgiven for not giving the disease much thought. But the mosquito-borne scourge is responsible for the deaths of nearly a million children under age 5 each year — mostly in Africa — killing one child every 30 seconds. Half the world's population remains at risk — including travelers to affected countries.

But while initiatives to provide insecticide-treated bed nets and other control measures have cut malaria rates in half in some countries, the disease is adapting, and insecticide-resistant and treatment-resistant strains are increasingly problematic. And the worldwide recession is reducing the funding available to keep malaria-control initiatives going. As a new avenue of attack, the PATH Malaria Vaccine Initiative (MVI) — which is funded by the Bill & Melinda Gates Foundation — on Friday, Jan. 15, announced a collaboration with the Johns Hopkins Bloomberg School of Public Health and the Sabin Vaccine Institute to create a whole new kind of malaria vaccine. Called a transmission-blocking vaccine (TBV), it is aimed not at protecting individuals from the disease but at preventing mosquitoes that carry it from spreading it.



Date Added: January 15 2010 Visits: 26
The Australian - November 3, 2009
Malaria vaccine available by 2015

LONDON: The first vaccine against malaria is likely to be distributed in Africa from 2015, after the "milestone moment" in the continent's largest final-stage drug trial.

A meeting of 1500 specialists in infectious diseases in Nairobi, Kenya, will be told today that more than 5500 children have been given the RTS,S vaccine, made by pharmaceutical company GlaxoSmithKline as part of the trial. Vaccine developers will tell the conference that the phase-three trial is under way in seven countries in Africa, marking a major step in bringing the drug to licence.
Date Added: December 30 2009 Visits: 40
Malaria Vaccine Initiative
The PATH Malaria Vaccine Initiative (MVI) is a global program of the international nonprofit organization PATH. MVI was established in 1999 through a grant from the Bill & Melinda Gates Foundation.
Date Added: December 22 2009 Visits: 33
New Scientist - August 14, 2009
Malaria vaccine holds out eradication hope

A VACCINE that targets the malaria parasite at a vulnerable point in its development could form part of a strategy to eradicate the disease.

Unlike other vaccines in the pipeline, which are designed to protect individuals who have been bitten, this one aims to sabotage the life cycle of the malaria parasite, Plasmodium, by stopping it from passing back from humans to mosquitoes
Date Added: October 02 2009 Visits: 182
US Navy Website -
Navy Researchers Work on Malaria Vaccine

WASHINGTON (NNS) -- Researchers at the Naval Medical Research Center are testing a malaria vaccine officials hope will protect both troops and civilians in tropical and subtropical regions afflicted by the disease.
Date Added: August 31 2009 Visits: 82
Virtual Medical Center
Fertilization points way to possible malaria vaccine - International investigations of an organism that one UT Southwestern Medical Center researcher calls a "silly little green scum" have led to key insights into the basic mechanisms of reproduction
Date Added: June 10 2008 Visits: 194